+1. If you excluded the NorbSoftDev and still no luck, as a last resort I would:Yeah, working in safe mode was probably a long shot. I suggest you try to disable all of Mcafee using msconfig.
Go to Start, Click on Run
Enter msconfig in the box and press OK
Go to the Services tab and uncheck anything having to do with Mcafee.
Do the same in the Startup tab.
Click OK and restart your computer.
Now see if the game will start.
Mcafee is probably the worst choice for AV software that can be made. Norton would be a close second.
1. Uninstall Mcafee completely.
2. Uninstall the game completely
3. Reinstall the game and patch to the latest.
4. Try running the game.
5. If that works, then install AVG viruscanner. Free and I've never had a problem with it. There's an option to exclude the NorbSoftDev directory in the options.